Researchers from the Karolinska Institutet have developed a new method (New techniques makes easy to study nanoparticles) to study the smallest elements in the body. This study, published in Nature Biotechnology, has great scientific potential, such as in creating more effective vaccines.
Distribute the environment in which nanoparticles are affected in one way or another. For example, there are lipoproteins that maintain cell metabolism, viruses that cause many diseases, and lipid nanoparticles that are used to carry drugs, such as anti-mRNA drugs based on lipid nanoparticles recently.
However, these particles are too small to be studied. To do this, the researchers in this study developed a new technique (New techniques makes easy to study nanoparticles) they call single-particle profiling (SPP).
“We offer a new method that provides unprecedented insight into nano-sized particles,” said the last author of the study, Assistant Professor Erdinc Sezgin at SciLifeLab at the Department of Health Women and Children, Karolinska Institutet says.
Allows the study of thousands of particles
This method makes it possible to measure the content and properties of thousands of particles whose size is between 5 and 200 nanometers.
“Our method can be used to study bioparticles in health and disease.” said Dr. Sezgin. “Furthermore, it will be a useful tool for creating efficient and effective nanocarriers.”
One of the researchers’ goals was to create a system that was simple, inexpensive, and accessible to all researchers.
“We established a system based on commercially available microscopes and made our data analysis tools and all our data available for free,” said Dr. Sezgin says.
Source: Karolinska Institutet
