• Latest
  • Trending
  • All

A Completely New Strategy Towards Optical Microscopy

August 8, 2021
New Printable, Injectable Materials for Advanced Medical Applications

New Printable, Injectable Materials for Advanced Medical Applications

May 29, 2025
Metal fleece: material for the batteries of the future

Metal fleece: material for the batteries of the future

May 24, 2025
AI and X-ray Vision to Gain Insight into Battery Electrolyte.

AI and X-ray Vision to Gain Insight into Battery Electrolyte

May 23, 2025
Mask users can now breathe easy on two counts

Mask users can now breathe easy on two counts

May 23, 2025
Boosting Cancer Treatment.

Boosting Cancer Treatment

May 23, 2025
Emergence Quantum: a commercial quantum research 'special ops' team

Emergence Quantum: a commercial quantum research ‘special ops’ team

May 22, 2025
Sugar-coated nanotherapy dramatically improves neuron survival in Alzheimer’s model.

Sugar-coated nanotherapy improves neuron survival

May 15, 2025
Quantum simulation of chemical dynamics achieved for first time

Quantum simulation of chemical dynamics achieved for first time

May 15, 2025
The mysterious chemical world inside nanopores.

The Mysterious Chemical World Inside Nanopores

May 13, 2025
Stability solution brings unique form of carbon closer to practical application.

Stability solution brings unique form of carbon closer to practical application

May 10, 2025
It’s Hard to Get Meds to the Lungs: Breathable Algae Offers a New Path.

It’s Hard to Get Meds to the Lungs: Breathable Algae Offers a New Path

May 7, 2025
New Bayesian Method Enables Rapid Detection of Quantum Dot Charge States

New Bayesian Method Enables Rapid Detection of Quantum Dot Charge States

May 2, 2025
  • About
  • Advertise
  • Privacy Policy
  • Terms & Conditions
  • Contact
Monday, June 2, 2025
  • Login
  • Register
Nanodigest
  • Home
  • Categories
    • Biological Science & Technology
    • Chemical Science & Technology
    • Material Science & Technology
    • Physical Science & Technology
    • Innovations & Education
  • NanoDigestExclusive
    AI and X-ray Vision to Gain Insight into Battery Electrolyte.

    AI and X-ray Vision to Gain Insight into Battery Electrolyte

    Emergence Quantum: a commercial quantum research 'special ops' team

    Emergence Quantum: a commercial quantum research ‘special ops’ team

    Couple satisfaction linked to fewer cognitive issues with chemo

    Ultrasound and Cilia to Clean Implanted Stents and Catheters

    Ultrasound and Cilia to Clean Implanted Stents and Catheters

    Celebrating Science

    Nobel prize for a New Way in Cancer Treatment

    Nobel prize for New Way in Cancer Treatment

    Simple to use device. Nano Digest.

    Simple to Use Device

    Nanofoam: Breakthrough in Material Design. Nano Digest.

    Nanofoam: Breakthrough in Material Design

    The Future of Solar Energy. Nano Digest.

    The Future of Solar Energy

    Trending Tags

    • 2D nanospace
    • 3D nano structures
    • Bacterial magnetic nanoparticle
    • Creation of nano technology
    • nano particles
    • Nano Technology
    • Nano Tv
    • nanomaterials
    • nanoparticles
    • Nanosciences
    • nanotubes
    • Nanowire
  • Nano TvYouTube
    Nanotechnology in Engineering – NANOENGINEERING | Nano Tv

    Nanotechnology in Engineering – NANOENGINEERING | Nano Tv

    nanotechnology, materials, graphene, nano digest, NanoTV

    Nanotechnology in Materials – GRAPHENE | Nano Tv

    Nanotechnology in Electronics - NANOELECTRONICS | Nano Tv, Nano Digest

    Nanotechnology in Electronics-NANOELECTRONICS | Nano Tv

    Nanotechnology in Medicine - NANOMEDICINE, Nano Tv, nano digest

    Nanotechnology in Medicine-NANOMEDICINE | Nano Tv

    Molecular Nanotechnology-NANOTECHNOLOGY & IMPLEMENTATIONS | Nano Tv, It deals with engineering nanoscale machines that operate on the molecular scale distinct from other areas of nanotechnology, such as nanoscale materials, nano digest

    Molecular Nanotechnology-NANOTECHNOLOGY & IMPLEMENTATIONS | Nano Tv

    What are Nanoparticles?, nano digest

    What are NANOPARTICLES?: Nano Tv

    THE ORIGIN & CHALLENGE by Richard Feynman | Nano Tv

    THE ORIGIN & CHALLENGE by Richard Feynman: Nano Tv

    Introduction, NANOTECHNOLOGY, nano digest, Nano Tv

    Introduction to NANOTECHNOLOGY | Nano Tv

  • ShopSale
No Result
View All Result
Nanodigest
No Result
View All Result
Home Physical Science & Technology

A Completely New Strategy Towards Optical Microscopy

by Nano Digest
August 8, 2021
in Physical Science & Technology
0
491
SHARES
1.4k
VIEWS
Share on FacebookShare on TwitterShare on Whatsapp
Photo Credit: © ChipScope

For half a millennium, people have tried to enhance human vision by technical means. While the human eye is capable of recognizing features over a wide range of size, it reaches its limits when peering at objects over giant distances or in the micro- and nanoworld. Researchers of the EU funded project ChipScope are now developing a completely new strategy towards optical microscopy.

The conventional light microscope, still standard equipment in laboratories, underlies the fundamental laws of optics. Thus, resolution is limited by diffraction to the so-called ‘Abbe limit’ – structural features smaller than a minimum of 200 nm cannot be resolved by this kind of microscope.

So far, all technologies for going beyond the Abbe limit rely on complex setups, with bulky components and advanced laboratory infrastructure. Even a conventional light microscope, in most configurations, is not suitable as a mobile gadget to do research out in the field or in remote areas. In the ChipScope project funded by the EU, a completely new strategy towards optical microscopy is explored. In classical optical microscopy the analyzed sample area is illuminated simultaneously, collecting the light which is scattered from each point with an area-selective detector, e.g. the human eye or the sensor of a camera. In the ChipScope idea instead, a structured light source with tiny, individually addressable elements is utilized. As depicted in the figure, the specimen is located on top of this light source, in close vicinity. Whenever single emitters are activated, the light propagation depends on the spatial structure of the sample, very similar to what is known as shadow imaging in the macroscopic world. To obtain an image, the overall amount of light that is transmitted through the sample region is sensed by a detector, activating one light element at a time and thereby scanning across the sample space. If the light elements have sizes in the nanometer regime and the sample is in close contact to them, the optical near field is of relevance and super resolution imaging may become possible with a chip-based setup.

To realize this alternative idea, a bunch of innovative technology is required. The structured light source is realized by tiny light-emitting diodes (LEDs), which are developed at the University of Technology in Braunschweig, Germany. Due to their superior characteristics in comparison to other lighting systems, e.g. the classical light bulb or Halogen-based emitters, LEDs have conquered the market for general lighting applications in the past decades. However, to the present point, no structured LED arrays with individually addressable pixels down to the sub-µm regime are commercially available. This task belongs to the responsibility of TU Braunschweig within the frame of the ChipScope project. First LED arrays with pixel sizes down to 1 µm have already been demonstrated by the researchers, as depicted in the figure. They are based on gallium nitride (GaN), a semiconductor material that is commonly used for blue and white LEDs. Controlled structuring of such LEDs down to the sub-µm regime is extremely challenging. It is conducted by photo- and electron beam lithography, where structures in the semiconductor are defined with high precision by optical shadow masks or focused electron beams.

As a further component, highly sensitive light detectors are required for the microscope prototype. Here, Professor A. Dieguez’ group at the University of Barcelona develops so called single-photon avalanche detectors (SPADs) which can detect very low light intensities down to single photons. First tests with those detectors integrated into a prototype of the ChipScope microscope have already been conducted and have shown promising results. Moreover, a way to bring specimens into close vicinity of the structured light source is vital for proper microscope operation. An established technology to realize this utilizes microfluidic channels, where a fine system of channels is structured into a polymer matrix. Using high-precision pumps, a micro-volume liquid is driven through this system and carries the specimen along to the target position. This part of the microscope assembly is contributed by the Austrian Institute of Technology AIT. Further partners: Medical Univ. of Vienna, Univ. Tor Vergata Roma, LMU Munich and FSRM, Switzerland.

Share196Tweet123Send
Nano Digest

Nano Digest

  • Trending
  • Comments
  • Latest

Nanotechnology in Cancer

September 10, 2020
Emergence of 2.5D Materials for Futuristic Applications

Emergence of 2.5D Materials for Futuristic Applications

June 29, 2022
New research methods developed for nano and quantum materials. Nano Digest.

New research methods developed for nano and quantum materials

February 24, 2023
Designing Gas detecting devices using nanomaterials. Nano Digest.

Designing Gas detecting devices using nanomaterials

2
3D Printing Allows Precise Light Control for Color Composition. nano Digest.

3D Printing Allows Precise Light Control for Color Composition

2

Wearable sensor monitors health, administers drugs using saliva and tears

1
New Printable, Injectable Materials for Advanced Medical Applications

New Printable, Injectable Materials for Advanced Medical Applications

May 29, 2025
Metal fleece: material for the batteries of the future

Metal fleece: material for the batteries of the future

May 24, 2025
AI and X-ray Vision to Gain Insight into Battery Electrolyte.

AI and X-ray Vision to Gain Insight into Battery Electrolyte

May 23, 2025
Nanodigest

Copyright © 2009-2022 NanoDigest.in

Navigate Site

  • About
  • Advertise
  • Privacy Policy
  • Terms & Conditions
  • Contact

Follow Us

No Result
View All Result
  • Home
  • Biological Science & Technology
  • Chemical Science & Technology
  • Material Science & Technology
  • Physical Science & Technology
  • Innovations & Education
  • NanoDigest Exclusive
  • Nano Tv
  • —————————–
  • About
  • Advertise
  • Contact
  • Privacy Policy
  • Terms & Conditions

Copyright © 2009-2022 NanoDigest.in

Welcome Back!

Sign In with Google
OR

Login to your account below

Forgotten Password? Sign Up

Create New Account!

Sign Up with Google
OR

Fill the forms below to register

*By registering into our website, you agree to the Terms & Conditions and Privacy Policy.
All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In
We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept All”, you consent to the use of ALL the cookies. However, you may visit "Cookie Settings" to provide a controlled consent.
Cookie SettingsAccept All
Manage consent

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
CookieDurationDescription
cookielawinfo-checkbox-analytics11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-functional11 monthsThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-performance11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy11 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
Functional
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
Performance
Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
Analytics
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
Advertisement
Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.
Others
Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.
SAVE & ACCEPT
This website uses cookies. By continuing to use this website you are giving consent to cookies being used. Visit our Privacy and Cookie Policy.