• Latest
  • Trending
  • All

Research exposes new vulnerability for SARS-CoV-2

August 7, 2021
It’s Hard to Get Meds to the Lungs: Breathable Algae Offers a New Path.

It’s Hard to Get Meds to the Lungs: Breathable Algae Offers a New Path

May 7, 2025
New Bayesian Method Enables Rapid Detection of Quantum Dot Charge States

New Bayesian Method Enables Rapid Detection of Quantum Dot Charge States

May 2, 2025
Unique molecule may lead to smaller, more efficient computers

Unique molecule may lead to smaller, more efficient computers

May 2, 2025
Depositing dots on corrugated chips improves photodetector capabilities.

Depositing dots on corrugated chips improves photodetector capabilities

May 2, 2025

Explaining the link between ‘good’ gut bacteria and rheumatoid arthritis

May 2, 2025
The way for scalable organic solar cells with enhanced thickness tolerance.

The way for scalable organic solar cells with enhanced thickness tolerance

May 1, 2025
Researchers advance toward a fault-tolerant quantum computer.

Researchers advance toward a fault-tolerant quantum computer

April 30, 2025

Couple satisfaction linked to fewer cognitive issues with chemo

April 30, 2025
AI Learns to Uncover the Hidden Atomic Structure of Crystals

AI Learns to Uncover the Hidden Atomic Structure of Crystals

April 29, 2025
Ultrasound and Cilia to Clean Implanted Stents and Catheters

Ultrasound and Cilia to Clean Implanted Stents and Catheters

April 29, 2025
Ultrafast electrical charging of liquids.

Ultrafast Electrical Charging of Liquids

April 28, 2025
Structure dictates effectiveness, safety in nanomedicine.

Structure dictates effectiveness, safety in nanomedicine

April 28, 2025
  • About
  • Advertise
  • Privacy Policy
  • Terms & Conditions
  • Contact
Friday, May 9, 2025
  • Login
  • Register
Nanodigest
  • Home
  • Categories
    • Biological Science & Technology
    • Chemical Science & Technology
    • Material Science & Technology
    • Physical Science & Technology
    • Innovations & Education
  • NanoDigestExclusive

    Couple satisfaction linked to fewer cognitive issues with chemo

    Ultrasound and Cilia to Clean Implanted Stents and Catheters

    Ultrasound and Cilia to Clean Implanted Stents and Catheters

    Celebrating Science

    Nobel prize for a New Way in Cancer Treatment

    Nobel prize for New Way in Cancer Treatment

    Simple to use device. Nano Digest.

    Simple to Use Device

    Nanofoam: Breakthrough in Material Design. Nano Digest.

    Nanofoam: Breakthrough in Material Design

    The Future of Solar Energy. Nano Digest.

    The Future of Solar Energy

    Transfer data and multiple lights at the same time. Nano Digest.

    Transfer data and multiple lights at the same time

    Creator of Lithium Ion Batteries, John Goodenough dies at 100

    Trending Tags

    • 2D nanospace
    • 3D nano structures
    • Bacterial magnetic nanoparticle
    • Creation of nano technology
    • nano particles
    • Nano Technology
    • Nano Tv
    • nanomaterials
    • nanoparticles
    • Nanosciences
    • nanotubes
    • Nanowire
  • Nano TvYouTube
    Nanotechnology in Engineering – NANOENGINEERING | Nano Tv

    Nanotechnology in Engineering – NANOENGINEERING | Nano Tv

    nanotechnology, materials, graphene, nano digest, NanoTV

    Nanotechnology in Materials – GRAPHENE | Nano Tv

    Nanotechnology in Electronics - NANOELECTRONICS | Nano Tv, Nano Digest

    Nanotechnology in Electronics-NANOELECTRONICS | Nano Tv

    Nanotechnology in Medicine - NANOMEDICINE, Nano Tv, nano digest

    Nanotechnology in Medicine-NANOMEDICINE | Nano Tv

    Molecular Nanotechnology-NANOTECHNOLOGY & IMPLEMENTATIONS | Nano Tv, It deals with engineering nanoscale machines that operate on the molecular scale distinct from other areas of nanotechnology, such as nanoscale materials, nano digest

    Molecular Nanotechnology-NANOTECHNOLOGY & IMPLEMENTATIONS | Nano Tv

    What are Nanoparticles?, nano digest

    What are NANOPARTICLES?: Nano Tv

    THE ORIGIN & CHALLENGE by Richard Feynman | Nano Tv

    THE ORIGIN & CHALLENGE by Richard Feynman: Nano Tv

    Introduction, NANOTECHNOLOGY, nano digest, Nano Tv

    Introduction to NANOTECHNOLOGY | Nano Tv

  • ShopSale
No Result
View All Result
Nanodigest
No Result
View All Result
Home Biological Science & Technology

Research exposes new vulnerability for SARS-CoV-2

by Nano Digest
August 7, 2021
in Biological Science & Technology
0
491
SHARES
1.4k
VIEWS
Share on FacebookShare on TwitterShare on Whatsapp
Research exposes new vulnerability for SARS-CoV-2

Northwestern University researchers have uncovered a new vulnerability in the novel coronavirus’ infamous spike protein—illuminating a relatively simple, potential treatment pathway.

The spike protein contains the virus’ binding site, which adheres to host cells and enables the virus to enter and infect the body. Using nanometer-level simulations, the researchers discovered a positively charged site (known as the polybasic cleavage site) located 10 nanometers from the actual binding site on the spike protein. The positively charged site allows strong bonding between the virus protein and the negatively charged human-cell receptors.

Leveraging this discovery, the researchers designed a negatively charged molecule to bind to the positively charged cleavage site. Blocking this site inhibits the virus from bonding to the host cell.

“Our work indicates that blocking this cleavage site may act as a viable prophylactic treatment that decreases the virus’ ability to infect humans,” said Northwestern’s Monica Olvera de la Cruz, who led the work. “Our results explain experimental studies showing that mutations of the SARS-CoV-2 spike protein affected the virus transmissibility.”

The research was published online last week in the journal ACS Nano.

Olvera de la Cruz is the Lawyer Taylor Professor of Materials Science and Engineering in Northwestern’s McCormick School of Engineering. Baofu Qiao, a research assistant professor in Olvera de la Cruz’s research group, is the paper’s first author.

Made up of amino acids, SARS-CoV-2’s polybasic cleavage sites have remained elusive since the COVID-19 outbreak began. But previous research indicates that these mysterious sites are essential for virulence and transmission. Olvera de la Cruz and Qiao discovered that polybasic cleavage site is located 10 nanometers from human cell receptors—a finding that provided unexpected insight.

“We didn’t expect to see electrostatic interactions at 10 nanometers,” Qiao said. “In physiological conditions, all electrostatic interactions no longer occur at distances longer than 1 nanometer.”

“The function of the polybasic cleavage site has remained elusive,” Olvera de la Cruz said. “However, it appears to be cleaved by an enzyme (furin) that is abundant in lungs, which suggests the cleavage site is crucial for virus entry into human cells.”

With this new information, Olvera de la Cruz and Qiao next plan to work with Northwestern chemists and pharmacologists to design a new drug that could bind to the spike protein.

Share196Tweet123Send
Nano Digest

Nano Digest

  • Trending
  • Comments
  • Latest

Nanotechnology in Cancer

September 10, 2020
Emergence of 2.5D Materials for Futuristic Applications

Emergence of 2.5D Materials for Futuristic Applications

June 29, 2022
New research methods developed for nano and quantum materials. Nano Digest.

New research methods developed for nano and quantum materials

February 24, 2023
Designing Gas detecting devices using nanomaterials. Nano Digest.

Designing Gas detecting devices using nanomaterials

2
3D Printing Allows Precise Light Control for Color Composition. nano Digest.

3D Printing Allows Precise Light Control for Color Composition

2

Wearable sensor monitors health, administers drugs using saliva and tears

1
It’s Hard to Get Meds to the Lungs: Breathable Algae Offers a New Path.

It’s Hard to Get Meds to the Lungs: Breathable Algae Offers a New Path

May 7, 2025
New Bayesian Method Enables Rapid Detection of Quantum Dot Charge States

New Bayesian Method Enables Rapid Detection of Quantum Dot Charge States

May 2, 2025
Unique molecule may lead to smaller, more efficient computers

Unique molecule may lead to smaller, more efficient computers

May 2, 2025
Nanodigest

Copyright © 2009-2022 NanoDigest.in

Navigate Site

  • About
  • Advertise
  • Privacy Policy
  • Terms & Conditions
  • Contact

Follow Us

No Result
View All Result
  • Home
  • Biological Science & Technology
  • Chemical Science & Technology
  • Material Science & Technology
  • Physical Science & Technology
  • Innovations & Education
  • NanoDigest Exclusive
  • Nano Tv
  • —————————–
  • About
  • Advertise
  • Contact
  • Privacy Policy
  • Terms & Conditions

Copyright © 2009-2022 NanoDigest.in

Welcome Back!

Sign In with Google
OR

Login to your account below

Forgotten Password? Sign Up

Create New Account!

Sign Up with Google
OR

Fill the forms below to register

*By registering into our website, you agree to the Terms & Conditions and Privacy Policy.
All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In
We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept All”, you consent to the use of ALL the cookies. However, you may visit "Cookie Settings" to provide a controlled consent.
Cookie SettingsAccept All
Manage consent

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
CookieDurationDescription
cookielawinfo-checkbox-analytics11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-functional11 monthsThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-performance11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy11 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
Functional
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
Performance
Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
Analytics
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
Advertisement
Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.
Others
Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.
SAVE & ACCEPT
This website uses cookies. By continuing to use this website you are giving consent to cookies being used. Visit our Privacy and Cookie Policy.